Codeine and its salts are well absorbed adhering to the two oral and parenteral administration. Codeine is about ⅔ as successful orally as parenterally. Codeine is metabolized principally in the liver by enzymes in the endoplasmic reticulum, wherever it undergoes O-demethylation, N-demethylation, and partial conjugation with glucuronic acid.
Anticholinergics – Concomitant utilization of other brokers with anticholinergic Attributes need to be carried out with warning.
This product or service may well include inactive elements, which could result in allergic reactions or other complications. Speak with your pharmacist for more details.
When supplied concomitantly with promethazine, the dose of barbiturates should be lessened by at the least just one-fifty percent, and the dose of narcotics ought to be decreased by just one-quarter to 1-50 %. Dosage need to be individualized. Extreme amounts of promethazine HCl relative to some narcotic might result in restlessness and motor hyperactivity in the affected individual with suffering; these indications generally vanish with suitable Charge of the pain.
g., All those with evidence of enhanced intracranial force or Mind tumors), Promethazine HCl and Codeine Phosphate Oral Remedy may possibly lower respiratory push, and also the resultant CO2 retention can further more increase intracranial stress. Also, opioids make adverse reactions that may obscure the clinical system of sufferers with head injuries.
This product may possibly include inactive ingredients, which could bring about allergic reactions or other issues. Check with your pharmacist For additional details.
A healthcare Experienced ought to be consulted in advance of using any drug, altering any diet program or commencing or discontinuing any class of treatment.
A Health care Qualified must be consulted in advance of taking any drug, transforming any diet plan or commencing or discontinuing any study course of cure.
Phenothiazines are linked to dystonic reactions, especially in pediatric individuals who definitely have an acute illness connected with dehydration. Paradoxical reactions, together with dystonia, torticollis, tongue protrusion, hyperexcitability, and abnormal movements are actually documented in clients subsequent one administration of promethazine. Discontinue Promethazine HCl and Codeine Phosphate Oral Solution if a paradoxical response takes place.
This isn't a whole listing of attainable Unintended effects. When you see other side effects not listed above, Make contact with your health practitioner or pharmacist.
This is very essential for elderly clients, who may very well be more sensitive to the consequences of agony medicines. If far too much of the drugs is taken for a very long time, it may turn into routine-forming (resulting in psychological or Bodily dependence) or bring about an overdose.
Respiratory depression bringing about arrest, coma, and Dying has happened with the usage of codeine antitussives in younger small children, especially from the under-a single-12 months infants whose capacity to deactivate the drug is not really absolutely formulated.
Codeine could cause significant unwelcome consequences if taken by adults, children, or Animals that are not utilized to strong narcotic discomfort medicines. Be sure you store the medicine in a secure and safe place to prevent Some others from finding it. Fall off any unused narcotic Promethazine codeine syrup medication at a drug just take-back place straight away.
Promethazine HCl and Codeine Phosphate Oral Option could cause serious hypotension such as orthostatic hypotension and syncope in ambulatory sufferers. There exists enhanced risk in patients whose ability to take care of blood pressure has by now been compromised by a lowered blood quantity or concurrent administration of particular CNS depressant drugs (e.